{"id":7793,"date":"2026-02-24T06:08:22","date_gmt":"2026-02-24T06:08:22","guid":{"rendered":"https:\/\/pandapeptides.com\/research\/oxytocin\/"},"modified":"2026-04-09T14:25:58","modified_gmt":"2026-04-09T21:25:58","slug":"oxytocin","status":"publish","type":"page","link":"https:\/\/pandapeptides.com\/es\/research\/oxytocin\/","title":{"rendered":"Oxytocin \u2014 Published Research"},"content":{"rendered":"
\n

\u2190 Back to Oxytocin product page<\/a><\/p>\n

\n

Biblioteca de investigaci\u00f3n<\/h3>\n

Published research on oxytocin \u2014 for educational purposes only<\/p>\n

\nOxytocin Receptor Signaling and G Protein Coupling<\/summary>\n
\n

The oxytocin receptor (OXTR) is a class A G protein-coupled receptor that primarily couples to G\u03b1q\/11, activating phospholipase C-\u03b2 and triggering IP\u2083-mediated calcium release from endoplasmic reticulum stores. OXTR also couples to G\u03b1i in some cellular contexts, inhibiting adenylyl cyclase. Receptor binding studies demonstrate high affinity for oxytocin (Ki ~1 nM) with lower affinity for the structurally related vasopressin peptide. OXTR expression varies across tissues and is regulated by estrogen and other factors.<\/p>\n

Gimpl G, Fahrenholz F. “The Oxytocin Receptor System: Structure, Function, and Regulation.” Physiol Rev.<\/em> 2001. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nOxytocin Receptor Pharmacology and Drug Design<\/summary>\n
\n

Research on OXTR pharmacology has focused on developing selective agonists and antagonists for receptor characterization. Structure-activity relationship studies have identified critical residues for receptor binding, including the Tyr\u00b2 and Ile\u00b3 positions as key determinants of OXTR versus vasopressin receptor selectivity. Cyclic and linear peptide analogs have been synthesized and characterized for potency, selectivity, and metabolic stability. Non-peptide OXTR ligands have also been developed as pharmacological tools for receptor studies.<\/p>\n

Manning M et al. “Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.” J Neuroendocrinol.<\/em> 2012. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nCentral Oxytocin Signaling Research<\/summary>\n
\n

Oxytocin neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) project to numerous brain regions including the amygdala, hippocampus, and nucleus accumbens. Central OXTR activation has been studied in relation to social behavior, stress responses, and reward circuitry using optogenetic, chemogenetic, and pharmacological approaches. Animal model studies have characterized oxytocin’s role in modulating neural circuits involved in social cognition and anxiety-related behaviors through electrophysiological and behavioral assays.<\/p>\n

Meyer-Lindenberg A et al. “Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine.” Nat Rev Neurosci.<\/em> 2011. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n<\/div>\n

\n

Disclaimer:<\/strong> All research citations are provided as references to published laboratory literature only. These materials may summarize in vitro and animal-model findings. Products are sold strictly for laboratory research use. No statements on this page are intended as dosing, administration, treatment, or other human-use guidance.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u2190 Back to Oxytocin product page Research Library Published research on oxytocin \u2014 for educational purposes only Oxytocin Receptor Signaling and G Protein Coupling The oxytocin receptor (OXTR) is a class A G protein-coupled receptor that primarily couples to G\u03b1q\/11, activating phospholipase C-\u03b2 and triggering IP\u2083-mediated calcium release from endoplasmic reticulum stores. OXTR also couples […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7787,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7793","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/comments?post=7793"}],"version-history":[{"count":1,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7793\/revisions"}],"predecessor-version":[{"id":8624,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7793\/revisions\/8624"}],"up":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7787"}],"wp:attachment":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/media?parent=7793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}