{"id":7794,"date":"2026-02-24T06:08:24","date_gmt":"2026-02-24T06:08:24","guid":{"rendered":"https:\/\/pandapeptides.com\/research\/hcg-human-chorionic-gonadotropin\/"},"modified":"2026-04-28T18:28:35","modified_gmt":"2026-04-29T01:28:35","slug":"hcg","status":"publish","type":"page","link":"https:\/\/pandapeptides.com\/es\/research\/hcg\/","title":{"rendered":"HCG \u2014 Published Research"},"content":{"rendered":"
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\u2190 Back to HCG (HCG) product page<\/a><\/p>\n

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Biblioteca de investigaci\u00f3n<\/h3>\n

Published research on HCG \u2014 for educational purposes only<\/p>\n

\nLHCGR signaling and cAMP pathway<\/summary>\n
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HCG interacts with LHCGR, a member of the glycoprotein hormone receptor subfamily of G protein-coupled receptors. Receptor activation couples primarily to G\u03b1s, stimulating adenylyl cyclase and increasing intracellular cAMP. In cell-based models, cAMP activates protein kinase A (PKA), which phosphorylates steroidogenic acute regulatory protein (StAR) and upregulates steroidogenic enzyme expression. The LHCGR also signals through G\u03b1q and \u03b2-arrestin pathways in certain cellular contexts. For laboratory research use only.<\/p>\n

Ascoli M et al. “The LH\/CG Receptor, A 2002 Perspective.” Endocr Rev.<\/em> 2002. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nLHCGR Structural Biology and Ligand Binding<\/summary>\n
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The LHCGR ectodomain contains leucine-rich repeats (LRRs) that form the primary hormone-binding interface. Cryo-EM and crystallographic studies have characterized the structural basis for HCG recognition, revealing that the \u03b1-subunit contacts the concave surface of the LRR domain while the \u03b2-subunit seatbelt loop wraps around the receptor. These structural studies inform understanding of receptor activation mechanisms and allosteric modulation in glycoprotein hormone signaling research. For laboratory research use only.<\/p>\n

Jiang X et al. “Structure of FSH in complex with the entire ectodomain of its receptor.” Proc Natl Acad Sci USA.<\/em> 2012. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nHCG Immunological Research<\/summary>\n
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Research has examined HCG’s interactions with immune cell populations beyond its classical reproductive endocrine functions. In vitro studies demonstrate HCG receptor expression on dendritic cells and regulatory T cells. HCG has been investigated for its effects on cytokine profiles, with studies examining IL-10, TGF-\u03b2, and pro-inflammatory cytokine modulation in immune cell culture models. This research characterizes potential extragonadal effects of glycoprotein hormone signaling in immunological contexts. For laboratory research use only.<\/p>\n

Schumacher A. “HCG as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance.” Front Immunol.<\/em> 2020. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Continue reviewing HCG<\/h3>\n

Use the research references above alongside Panda\u2019s batch documentation and catalog specifications.<\/p>\n

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Disclaimer:<\/strong> All research citations are provided as references to published laboratory literature only. These materials may summarize in vitro and animal-model findings. Products are sold strictly for laboratory research use only. This page is provided for research-reference and documentation review only.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u2190 Back to HCG (HCG) product page Research Library Published research on HCG \u2014 for educational purposes only LHCGR signaling and cAMP pathway HCG interacts with LHCGR, a member of the glycoprotein hormone receptor subfamily of G protein-coupled receptors. Receptor activation couples primarily to G\u03b1s, stimulating adenylyl cyclase and increasing intracellular cAMP. In cell-based models, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7787,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7794","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/comments?post=7794"}],"version-history":[{"count":5,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794\/revisions"}],"predecessor-version":[{"id":9434,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794\/revisions\/9434"}],"up":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7787"}],"wp:attachment":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/media?parent=7794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}