{"id":7794,"date":"2026-02-24T06:08:24","date_gmt":"2026-02-24T06:08:24","guid":{"rendered":"https:\/\/pandapeptides.com\/research\/hcg-human-chorionic-gonadotropin\/"},"modified":"2026-04-09T14:25:59","modified_gmt":"2026-04-09T21:25:59","slug":"hcg","status":"publish","type":"page","link":"https:\/\/pandapeptides.com\/es\/research\/hcg\/","title":{"rendered":"HCG (Human Chorionic Gonadotropin) \u2014 Published Research"},"content":{"rendered":"
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\u2190 Back to HCG (Human Chorionic Gonadotropin) product page<\/a><\/p>\n

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Biblioteca de investigaci\u00f3n<\/h3>\n

Published research on HCG \u2014 for educational purposes only<\/p>\n

\nLH\/CG Receptor Signaling and cAMP Pathway<\/summary>\n
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HCG binds to the luteinizing hormone\/choriogonadotropin receptor (LHCGR), a member of the glycoprotein hormone receptor subfamily of G protein-coupled receptors. Receptor activation couples primarily to G\u03b1s, stimulating adenylyl cyclase and increasing intracellular cAMP. In cell-based models, cAMP activates protein kinase A (PKA), which phosphorylates steroidogenic acute regulatory protein (StAR) and upregulates steroidogenic enzyme expression. The LHCGR also signals through G\u03b1q and \u03b2-arrestin pathways in certain cellular contexts. Research compound \u2014 not for human use.<\/p>\n

Ascoli M et al. “The Lutropin\/Choriogonadotropin Receptor, A 2002 Perspective.” Endocr Rev.<\/em> 2002. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nLHCGR Structural Biology and Ligand Binding<\/summary>\n
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The LHCGR ectodomain contains leucine-rich repeats (LRRs) that form the primary hormone-binding interface. Cryo-EM and crystallographic studies have characterized the structural basis for HCG recognition, revealing that the \u03b1-subunit contacts the concave surface of the LRR domain while the \u03b2-subunit seatbelt loop wraps around the receptor. These structural studies inform understanding of receptor activation mechanisms and allosteric modulation in glycoprotein hormone signaling research. Research compound \u2014 not for human use.<\/p>\n

Jiang X et al. “Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor.” Proc Natl Acad Sci USA.<\/em> 2012. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nHCG Immunological Research<\/summary>\n
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Research has examined HCG’s interactions with immune cell populations beyond its classical reproductive endocrine functions. In vitro studies demonstrate HCG receptor expression on dendritic cells and regulatory T cells. HCG has been investigated for its effects on cytokine profiles, with studies examining IL-10, TGF-\u03b2, and pro-inflammatory cytokine modulation in immune cell culture models. This research characterizes potential extragonadal effects of glycoprotein hormone signaling in immunological contexts. Research compound \u2014 not for human use.<\/p>\n

Schumacher A. “Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance.” Front Immunol.<\/em> 2020. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Disclaimer:<\/strong> All research citations are provided as references to published laboratory literature only. These materials may summarize in vitro and animal-model findings. Products are sold strictly for laboratory research use. No statements on this page are intended as dosing, administration, treatment, or other human-use guidance.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u2190 Back to HCG (Human Chorionic Gonadotropin) product page Research Library Published research on HCG \u2014 for educational purposes only LH\/CG Receptor Signaling and cAMP Pathway HCG binds to the luteinizing hormone\/choriogonadotropin receptor (LHCGR), a member of the glycoprotein hormone receptor subfamily of G protein-coupled receptors. Receptor activation couples primarily to G\u03b1s, stimulating adenylyl cyclase […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7787,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7794","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/comments?post=7794"}],"version-history":[{"count":2,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794\/revisions"}],"predecessor-version":[{"id":8625,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7794\/revisions\/8625"}],"up":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7787"}],"wp:attachment":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/media?parent=7794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}