{"id":7805,"date":"2026-02-24T06:08:29","date_gmt":"2026-02-24T06:08:29","guid":{"rendered":"https:\/\/pandapeptides.com\/research\/mots-c\/"},"modified":"2026-04-09T14:26:13","modified_gmt":"2026-04-09T21:26:13","slug":"mots-c","status":"publish","type":"page","link":"https:\/\/pandapeptides.com\/es\/research\/mots-c\/","title":{"rendered":"MOTS-c \u2014 Published Research"},"content":{"rendered":"
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\u2190 Back to MOTS-c product page<\/a><\/p>\n

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Biblioteca de investigaci\u00f3n<\/h3>\n

Published research on MOTS-c \u2014 for educational purposes only<\/p>\n

\nMOTS-c Discovery and Mitochondrial Encoding<\/summary>\n
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MOTS-c was identified in 2015 as a peptide encoded within a short open reading frame in the 12S rRNA region of mitochondrial DNA. Unlike nuclear-encoded peptides, MOTS-c is translated using the mitochondrial genetic code and exported to the cytoplasm and circulation. Plasma MOTS-c levels have been measured in humans and show variation with age and metabolic state. The discovery of MOTS-c expanded the concept of mitochondria as signaling organelles that communicate with the nucleus and other tissues.<\/p>\n

Lee C et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metab.<\/em> 2015. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nAMPK Activation and Metabolic Signaling<\/summary>\n
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MOTS-c activates AMP-activated protein kinase (AMPK), the master regulator of cellular energy homeostasis. The mechanism involves MOTS-c inhibition of the folate-methionine cycle, specifically by binding to and inhibiting methionine adenosyltransferase 2A (MAT2A), leading to decreased S-adenosylmethionine (SAM) levels and de-repression of AMPK. AMPK activation then stimulates glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while inhibiting lipogenesis and gluconeogenesis.<\/p>\n

Reynolds JC et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nat Commun.<\/em> 2021. PubMed<\/a><\/p>\n<\/div>\n<\/details>\n

\nMOTS-c Nuclear Translocation and Gene Regulation<\/summary>\n
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Under metabolic stress conditions, MOTS-c translocates to the nucleus where it regulates gene expression involved in cellular stress responses. Nuclear MOTS-c interacts with ARE (antioxidant response element)-containing gene promoters and modulates transcription of genes including NRF2 targets. This represents a unique form of retrograde signaling where a mitochondrial-encoded peptide directly regulates nuclear gene transcription. Exercise increases MOTS-c nuclear translocation in skeletal muscle cells.<\/p>\n

Kim KH et al. “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.” Free Radic Biol Med.<\/em> 2018. PMC<\/a><\/p>\n<\/div>\n<\/details>\n<\/div>\n

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Disclaimer:<\/strong> All research citations are provided as references to published laboratory literature only. These materials may summarize in vitro and animal-model findings. Products are sold strictly for laboratory research use. No statements on this page are intended as dosing, administration, treatment, or other human-use guidance.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u2190 Back to MOTS-c product page Research Library Published research on MOTS-c \u2014 for educational purposes only MOTS-c Discovery and Mitochondrial Encoding MOTS-c was identified in 2015 as a peptide encoded within a short open reading frame in the 12S rRNA region of mitochondrial DNA. Unlike nuclear-encoded peptides, MOTS-c is translated using the mitochondrial genetic […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7787,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7805","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/comments?post=7805"}],"version-history":[{"count":1,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7805\/revisions"}],"predecessor-version":[{"id":8636,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7805\/revisions\/8636"}],"up":[{"embeddable":true,"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/pages\/7787"}],"wp:attachment":[{"href":"https:\/\/pandapeptides.com\/es\/wp-json\/wp\/v2\/media?parent=7805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}