Research Summary: C is a long-acting acylated amylin analog that activates AMY1, AMY2, AMY3, and calcitonin receptors. CAS 2196055-94-8. Half-life extended via C18 fatty diacid albumin binding. Structurally and mechanistically distinct from GLP-1 receptor agonists. Research peptide only.
Compound Specifications
C is a long-acting synthetic amylin analog — distinct from the GLP-1 receptor agonist class. CAS Registry Number: 2196055-94-8. Binds AMY1R, AMY2R, AMY3R, and calcitonin receptor (CTR). Features N-terminal lipidation (C-18 fatty diacid) enabling albumin binding for extended pharmacokinetic half-life. Research compound only.
Product Details
- Sizes: 5mg, 10mg
- Compound: C
- Classification: Dual amylin/calcitonin receptor agonist (DACRA)
- Purity: >99%
- Form: Lyophilized powder
- Testing: View COA (Verified by Janoshik) →
mg, 10mg
Research Studies
(for educational purposes only)
Amylin Receptor Subtypes and Signal Transduction
Source: PubMed PMID: 25733553
Summary: This review characterized amylin receptor pharmacology, examining how receptor activity-modifying proteins (RAMPs 1-3) combine with the calcitonin receptor to form distinct AMY1R, AMY2R, and AMY3R subtypes with different signaling profiles and tissue distribution patterns in cell-based assays.
Structural Basis of Calcitonin and Amylin Receptor Activation
Source: Nature Communications
Summary: Cryo-EM structural studies characterized the binding modes of long-acting amylin analogs at calcitonin and amylin receptor complexes, revealing how N-terminal lipidation affects receptor engagement geometry and G-protein coupling efficiency in reconstituted membrane systems.
📚 View Published Research on C →
Peer-reviewed citations from PubMed — for educational purposes only