Research Summary: S (GLP-1 S) is a selective GLP-1 receptor agonist with 94% homology to native GLP-1. CAS 910463-68-2. Features Aib8 substitution for DPP-4 resistance; C18 fatty diacid enables extended half-life via non-covalent albumin binding. Research peptide only.
Compound Specifications
GLP-1 S is a synthetic GLP-1 receptor agonist with 94% structural homology to native human GLP-1(7-37). CAS Registry Number: 910463-68-2. Molecular weight: ~4,113.58 Da. Features a C-18 fatty di-acid chain conjugated at position 26 (Lys26) enabling non-covalent albumin binding for extended pharmacokinetic half-life. Research compound only.
Product Details
- Compound: GLP-1 S
- Classification: GLP-1 receptor agonist
- Purity: >99%
- Form: Lyophilized powder
- Sizes: 5mg, 10mg
- Testing: View COA (Verified by Janoshik) →
Research Studies
(for educational purposes only)
GLP-1 Receptor Signal Transduction
Source: PubMed PMID: 23684623
Summary: This review characterized GLP-1 receptor pharmacology, examining Gαs-coupled cAMP/PKA signaling, β-arrestin recruitment, and downstream Epac2-mediated pathways in pancreatic beta-cell models and neuronal cell lines.
Fatty Acid Acylation and Albumin Binding Pharmacokinetics
Source: PubMed PMID: 26308095
Summary: This medicinal chemistry study described the design and structure-activity relationships of GLP-1 analogs with C-18 fatty diacid modifications. Research characterized how the acyl chain length, linker chemistry, and attachment position influence albumin binding affinity and proteolytic stability in vitro.
📚 View Published Research on GLP-1 S →
Peer-reviewed citations from PubMed — for educational purposes only