Research Summary: GLP-1T is an imbalanced dual GIP/GLP-1 receptor agonist exhibiting biased agonism with reduced β-arrestin recruitment at GLP-1R. CAS 2023788-19-2. 39-amino acid peptide with C20 fatty diacid for ~5-day half-life. Published in JCI Insight and PNAS. Research peptide only.
GLP-1T
Dual GIP/GLP-1 Receptor Agonist — For Research Use Only
GLP-1T is a 39-amino acid synthetic dual GIP/GLP-1 receptor agonist classified as an imbalanced twincretin peptide. CAS Registry Number: 2023788-19-2. Molecular weight: ~4,813.45 Da. Molecular formula: C₂₂₅H₃₄₈N₄₈O₆₈. Research compound supplied as lyophilized powder for investigational use only.
Product Details
- Compound: GLP-1T
- Classification: Dual incretin receptor agonist
- Purity: >99% (HPLC verified)
- Form: Lyophilized powder
- Testing: View COA (Verified by Janoshik) →
Research Studies
(for educational purposes only)
Imbalanced dual GIP/GLP-1 receptor agonist profile
Willard FS, Douros JD, Gabe MBN, et al. · JCI Insight
Investigated GLP-1T’s pharmacological profile as a dual receptor agonist, examining binding affinity and signaling patterns at GIP and GLP-1 receptors.
Broader β cell signaling and cytoprotective effects
Min Q, Bhatt DK, Mercer AJ, et al. · PNAS
Examined GLP-1T’s biased signaling at the GLP-1 receptor, investigating cAMP production and receptor internalization patterns.
📚 View Published Research on GLP-1T →
Peer-reviewed citations from PubMed — for educational purposes only
FOR RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
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