MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA gene (MT-RNR1), molecular weight 2174 Da. It activates AMPK and regulates metabolic homeostasis. Research examines its effects on glucose uptake, glucose uptake pathways, and mitochondrial function in metabolic studies. Research compound — for laboratory use only.
Compound Specifications
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) encoded within the mitochondrial genome. Molecular weight approximately 2174 Da. MOTS-c is a member of the mitochondrial-derived peptide (MDP) family and is characterized by retrograde signaling from mitochondria to the nucleus to regulate metabolic gene expression. Research compound — for laboratory use only.
Product Details
- Compound: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
- Sequence: MRWQEMGYIFYPRKLR
- Purity: >99%
- Form: Lyophilized powder
- Sizes: 10mg, 40mg
- Testing: View COA (Verified by Janoshik) →
📚 View Published Research on MOTS-c →
Peer-reviewed citations from PubMed — for educational purposes only




