Research Summary: R (GLP-G3) is a triple GIP/GLP-1/glucagon receptor agonist (LY3437943). CAS 2381089-83-2. Single alpha-helical peptide with engineered multi-receptor selectivity; C20 fatty diacid for extended activity. Research peptide only.
Compound Specifications
GLP-G3 is a triple incretin receptor agonist engaging GLP-1, GIP, and glucagon (GCGR) receptors simultaneously. CAS Registry Number: 2381089-83-2. Molecular weight: ~4,632.28 Da. Features a single alpha-helical peptide structure with engineered selectivity across all three receptor types. Research compound only.
Product Details
- Compound: GLP-G3
- Classification: Triple incretin receptor agonist
- Purity: >99%
- Form: Lyophilized powder
- Sizes: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg
- Testing: View COA (Verified by Janoshik) →
Research Studies
(for educational purposes only)
Triple Receptor Agonism: GLP-1/GIP/GCGR Mechanism
Source: PubMed PMID: 36070752
Summary: This study characterized GLP-G3 as a single-molecule triple agonist in receptor binding and cell-based signaling assays, demonstrating simultaneous engagement of GLP-1R, GIPR, and glucagon receptor with distinct potency ratios. Preclinical models examined the pharmacological consequences of concurrent activation of all three receptor systems.
Glucagon Receptor Signaling and Hepatic Energy Metabolism
Source: PubMed PMID: 25365075
Summary: This review examined glucagon receptor (GCGR) pharmacology, characterizing Gαs-coupled cAMP signaling in hepatocytes and its downstream effects on glycogenolysis, gluconeogenesis, and fatty acid oxidation pathways in cell and animal models. Research relevant to understanding the glucagon component of multi-receptor agonists.
📚 View Published Research on GLP-G3 →
Peer-reviewed citations from PubMed — for educational purposes only
