PT-141 is a synthetic cyclic heptapeptide. CAS 189691-06-3. Molecular weight 1025.2 Da. Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. Supplied as a lyophilized powder, >99% purity by HPLC. Research compound — not for human use.
Compound Specifications
Product Details
- Compound: PT-141
- CAS: 189691-06-3
- Molecular Weight: 1025.2 Da
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Structure: Cyclic heptapeptide with lactam bridge between Asp and Lys
- Purity: >99% (Janoshik verified, HPLC)
- Form: Lyophilized powder
- Storage: -20°C desiccated
- Testing: View COA (Verified by Janoshik) →
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Structural Characterization
PT-141 is a compact macrocyclic peptide whose constrained geometry is defined by a lactam linkage between the aspartyl and lysyl residues. The sequence contains norleucine, aromatic residues, and basic side chains, giving the compound a mixed hydrophobic and cationic profile in laboratory characterization.
- Peptide Class: Cyclic heptapeptide with C-terminal free acid
- Conformation: Lactam-constrained macrocycle
- UV Absorption: Aromatic residue signal from Trp and Phe chromophores
- Appearance: White to off-white lyophilized powder
Physicochemical Notes
- Solubility: Soluble in aqueous laboratory buffers
- Charge Profile: Mixed cationic and hydrophobic residue distribution
- Handling: Best stored frozen, dry, and protected from prolonged light exposure